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Tg(Camk2a-cre/ERT2)1Aibs - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Camk2a-cre/ERT2)1Aibs
transgene insertion 1, Allen Institute for Brain Science 		Driver: Camk2a
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Camk2a-CreERT2
Molecular description: The Camk2a-CreERT2 transgene was designed with the mouse Camk2a promoter, CreERT2 fusion gene, a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), bovine growth hormone polyA signal, and PGK-Puro-SV40polyA cassette. (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells, already targeted with an Ai3 mutation in the Gt(ROSA)26Sor locus, were transfected with the Camk2a-CreERT2 transgene. Correctly targeted ES cells harboring both the Ai3 mutation and Camk2a-CreERT2 transgene were injected into recipient blastocysts. The resulting chimeric animals were bred to C57BL/6J mice to generate the double mutant colony. Subsequent mating with C57BL/6J wildtype mice resulted in offspring harboring only the Camk2a-CreERT2 transgene (wildtype at the Gt(ROSA)26Sor locus).
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Camk2a-cre/ERT2)1Aibs activity also observed in:
alimentary system, head, muscle, nervous system, renal & urinary system, sensory organs
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:232845 Full Image
Fig. Camk2a adult Islets of Langerhans J:232845 Full Image
Fig. Camk2a adult Pituitary Gland
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 55 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory