Cyp11a1<tm1(GFP/cre)Pzg> - Alimentary System Recombinase Activity Detail MGI Mouse

Cyp11a1^{tm1(GFP/cre)Pzg} - Alimentary System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Cyp11a1^{tm1(GFP/cre)Pzg}
cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 1, Pumin Zhang

Driver: Cyp11a1
Type: Targeted (Recombinase)

Synonym:

Cyp11a1-GFP-Cre, Cyp11a1^{tm1(GFP/cre)Zhang}

Molecular description:

A targeting vector containing a GFP-Cre cassette (GC) and a FRT site-flanked kanamycin and neomycin resistance cassette was inserted into the first coding exon of the endogenous gene immediately following the ATG translation initiation codon. Although no green fluorescence is visible in whole heterozygous mutant E15.5 embryos or their urogenital tracts, immunohistochemical analysis detects GFP protein in their kidneys and testes. In E15.5 embryos bearing this allele and a Cre recombinase-inducible lacZ reporter gene, beta-galactosidase activity is detected by X-gal staining in kidneys and adrenals of both sexes and in testes.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Cyp11a1^{tm1(GFP/cre)Pzg} activity also observed in:
endocrine system, head, nervous system, reproductive system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

7 reference(s)

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