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Cyp11a1tm1(GFP/cre)Pzg - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Cyp11a1tm1(GFP/cre)Pzg
cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 1, Pumin Zhang 		Driver: Cyp11a1
Type: Targeted (Recombinase)
Synonym: Cyp11a1-GFP-Cre, Cyp11a1tm1(GFP/cre)Zhang
Molecular description: A targeting vector containing a GFP-Cre cassette (GC) and a FRT site-flanked kanamycin and neomycin resistance cassette was inserted into the first coding exon of the endogenous gene immediately following the ATG translation initiation codon. Although no green fluorescence is visible in whole heterozygous mutant E15.5 embryos or their urogenital tracts, immunohistochemical analysis detects GFP protein in their kidneys and testes. In E15.5 embryos bearing this allele and a Cre recombinase-inducible lacZ reporter gene, beta-galactosidase activity is detected by X-gal staining in kidneys and adrenals of both sexes and in testes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Cyp11a1tm1(GFP/cre)Pzg activity also observed in:
endocrine system, head, nervous system
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Images
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J:212212 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory