A targeting vector was generated that contained 5 + 3' homology arms to the first intron of the Gt(ROSA)26Sor locus, a cassette containing a splice acceptor, the improved rtTA-M2 element followed by a human TP53 intron and in opposite orientation, the tet-response element TRE-tight promoter driving a cre coding sequence (tetO-cre). The vector also contained an FRT-flanked neo selection cassette. Homologous recombination was done in R1 ES cells. Germline mice were produced and subsequently crossed to Flpe deleter mice to delete the neo cassette.
Find mice (IMSR):
Mouse Strains:
0 strains available
Cell Lines:
0 lines available
Additional Tissues:
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn activity also observed in:
This site uses cookies.
Some cookies are essential for site operations and others help us analyze use and utility of our web site.
Please refer to our
privacy policy
for more information.
Analysis Tools
