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Tg(Slc6a5-icre)121Veul - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc6a5-icre)121Veul
transgene insertion 121, Volker Eulenburg 		Driver: Slc6a5
Type: Transgenic (Recombinase)
Synonym: GlyT2-Cre
Molecular description: A BAC containing all coding exons of Slc6a5 and the 5' UTR was modified using a 2-step homologous recombination method resulting in the coding sequence for a codon-optimized cre (icre) including the nuclear localization signal being inserted in frame into exon 2. The modifed BAC was linearized and injected into B6D2F1 single cell zygotes. Seven founder which transmitted the transgene were obtained and five lines were analyzed (lines 118 (5 transgene copies), 121 (1 copy), 122.2 (1 copy), 122.4 (1 copy), and 128 (2 copies)). Line 121 was analyzed in greater detail.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc6a5-icre)121Veul activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:160216 Fig. 3 J:160216 Fig. 4 J:160216 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory