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Tg(Aire-cre)410-5Mmat - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Aire-cre)410-5Mmat
transgene insertion 410-5, Mitsuru Matsumoto 		Driver: Aire
Type: Transgenic (Recombinase)
Synonym: Aire/Cre BAC Tg line 410-5
Molecular description: The BAC RP23-461E7 containing the Aire locus was modified to replace the Aire start codon with the open reading frame of cre recombinase followed by the rabbit beta-globin polyA signal, using the Red/ET Counter Selection BAC Modification kit. The linearized BAC construct was injected into pronuclei of fertilized C57BL/6 oocytes. Multiple founders were generated. When crossed to a reporter mouse strain, lines410-4, 413-3, 4155-2, and 461-1 displayed GFP expression in the entire thymus region, as well as in all tissues examined (as result of embryonic expression in all three germ layers.) GFP expression was confined to particular thymic components or cells in two other lines (410-3 and 410-5). Line 410-5 was characterized in more detail, and two distinct patterns of expression were observed.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Aire-cre)410-5Mmat activity also observed in:
alimentary system, head, hemolymphoid system, integumental system, renal & urinary system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:160217 Fig. S2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory