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Tg(Runx2-icre)1Jtuc - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Runx2-icre)1Jtuc
transgene insertion 1, Jan Tuckermann 		Driver: Runx2
Type: Transgenic (Recombinase)
Synonym: Runx2-Cre, Runx2Cre
Molecular description: A BAC containing the Runx2 locus was modified through ET recombination to insert a codon-improved cre recombinase sequence and an ampicillin resistance gene flanked by two FRT sites at the translational start site of the distal promoter (P1) of the Runx2 gene. Subsequently in the recombinant BAC, the ampicillin resistance cassette was removed by arabinose-induced FLP recombination.The linearized construct was injected into the pronuclei of FVB/N oocytes. Three founder lines were established and one was chosen for experimental use based on its expression pattern.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Runx2-icre)1Jtuc activity also observed in:
head, limbs, mouse-other
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 26 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory