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Tg(ATP6V1B1-cre)45Rnel - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(ATP6V1B1-cre)45Rnel
transgene insertion 45, Raoul Nelson 		Driver: ATP6V1B1
Type: Transgenic (Recombinase)
Synonym: B1-Cre, VB1Cre
Molecular description: 7 kb of the 5' UTR of the human ATP6V1B1 gene (B1 promoter region) was cloned upstream of cre recombinase in the construct. The purified transgene fragment was injected into single-cell embryos. 50 founders were produced, and line 45 was analyzed further. Founders were bred onto a C57BL/6 x CBA background. Cre activity was assessed by crossing cre transgenic animals to mice carrying a floxed fluorescent reporter. Activity was observed in all intercalated cells in the collecting duct and in most cells of the connecting segment (including about half of the principal cells) and in the male reproductive tract, while low levels of activity were identified in non-ATP6V1B1 expressing tissues including the brain, large and small intestine, and uterus. No expression was detected in liver, stomach, skeletal muscle, heart or spleen.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(ATP6V1B1-cre)45Rnel activity also observed in:
alimentary system, head, renal & urinary system, reproductive system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory