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Tg(Dbh-cre/ERT2)198.1Hroh - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Dbh-cre/ERT2)198.1Hroh
transgene insertion 198.1, Hermann Rohrer 		Driver: Dbh
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: DBHCreERT2, DBH-CT198.1
Molecular description: A cre-ERT2 cassette with a polyA sequence was inserted into a BAC containing the mouse Dbh gene by homologous recombination, resulting in cre expression directed by the Dbh promoter. This construct was integrated into the C57BL/6 background. Cre induction by tamoxifen in mice crossed to a reporter line exhibited cre activity in noradrenergic cells (sympathetic ganglia, adrenal chromaffin cells, and the locus ceruleus).
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Dbh-cre/ERT2)198.1Hroh activity also observed in:
endocrine system, head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:180731 Fig. 2 J:180731 Fig. 3 J:180731 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory