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Ssttm2.1(cre)Zjh - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Ssttm2.1(cre)Zjh
somatostatin; targeted mutation 2.1, Z Josh Huang 		Driver: Sst
Type: Targeted (Knockdown, Recombinase)
Synonym: SOM-iCre, SOM-IRES-Cre, SSTCre, Sst-iCre, Sst-IRES-Cre
Molecular description: A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the somatostatin locus (Sst). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. This mutation results in a dosage-dependent knock-down of endogenous Sst expression J:279254 .
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Ssttm2.1(cre)Zjh activity also observed in:
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:184579 Full Image
Fig. Sst Embryo E15.5 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 591 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory