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Tg(Slc17a6-icre)1Oki - Embryo-other
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc17a6-icre)1Oki
transgene insertion 1, Ole Kiehn 		Driver: Slc17a6
Type: Transgenic (Recombinase)
Synonym: BAC-Vglut2::Cre, vGlut2Cre
Molecular description: Recombineering methods in bacterial cells were used to insert the codon-improved cre open reading frame and FRT-flanked ampicillin resistance gene after the ATG site of the Slc17a6 locus contained in BAC clone RP23-84M15. Insertion of the targeting construct resulting in inactivation of the Slc17a6 gene in the BAC. Flpe recombinase was induced in the bacterial cells and the ampicillin cassette was excised. The purified 201 kb final construct was injected into the pronuclei of C57BL/6 zygotes. Three positive founders were produced. All founders exhibited similar restricted cre expression in the spinal cord, so a line produced from one founder was analyzed further.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc17a6-icre)1Oki activity also observed in:
head, nervous system
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 27 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory