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Tg(BEST1-cre)1Jdun - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
Tg(BEST1-cre)1Jdun
transgene insertion 1, Joshua L Dunaief 		Driver: BEST1
Type: Transgenic (Recombinase)
Synonym: BEST1-cre
Molecular description: A fragment of the human BEST1 promoter (nucleotides -585 to +38) drives cre recombinase cDNA, the SV40 t-antigen intron, and HSV-TK polyA in the construct. This was purified and microinjected into C57BL/6 zygotes. Six founders were generated with one F2 line that showed the highest percentage of cre immunoreactivity in the RPE was selected for further study. Expression of cre was mosaic, with 50-90% of RPE cells being labeled. This line has a transgene copy number of 20 determined by qPCR analysis (J:170522) or 5 copies (J:240920) inserted about 58 kb upstream of Tmem108 (chr9:103,722,073; NCBI37/mm9) with a 120 bp deletion at the transgene integration site.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(BEST1-cre)1Jdun activity also observed in:
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Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 42 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory