Tg(Col1a1-cre/ERT2)1Crm - Muscle Recombinase Activity Detail MGI Mouse

Tg(Col1a1-cre/ERT2)1Crm - Muscle
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Col1a1-cre/ERT2)1Crm
transgene insertion 1, Benoit de Crombrugghe

Driver: Col1a1
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Col1a1-CreERT2

Molecular description:

The transgene consists of a tamoxifen-inducible cre recombinase driven by the 2.3-kb mouse Col1a1, collagen, type I, alpha 1, promoter. The transgene insert contains a fusion product involving cre recombinase and a mutant form of the mouse estrogen receptor ligand binding domain. The mutant mouse estrogen receptor does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Inducible cre recombinase activity is detected in the osteoblasts of the long bones of the limbs and in the ribs, vertebrae and calvaria in 18.5 embryonic day aged and 18 day old mice. Inducible cre recombinase activity was not detected in chondrocytes.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Col1a1-cre/ERT2)1Crm activity also observed in:

alimentary system, embryo-other, head, integumental system ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

31 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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