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Tg(Phox2b-cre)3Jke - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Phox2b-cre)3Jke
transgene insertion 3, Joel K Elmquist 		Driver: Phox2b
Type: Transgenic (Recombinase)
Synonym:
Molecular description: The mouse BAC RP24-95M11, containing the entire Phox2b locus and 130kb sequence upstream of the Phox2b locus (including part of the Limch1 locus) and 70kb of sequence downstream of the Phox2b locus was modified to produce the construct. A Cre recombinase sequence fused with an frt-flanked neomycin gene was inserted into the ATG start site of the Phox2b locus via homologous recombination/BAC recombineering. The frt-flanked neo was removed via transient transfection of an FLP-expressing vector during BAC recombineering. The resulting ~200 kb Phox2b-Cre BAC transgene was injected into C57BL/6J mouse pronuclei to produce independent founder lines. Founder line 3 was found with the greatest degree of nucleus of the solitary tract (NTS) cells expressing Cre recombinase.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Phox2b-cre)3Jke activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:331457 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 42 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory