Cck<tm1.1(cre)Zjh> - Embryo-other Recombinase Activity Detail MGI Mouse

Cck^{tm1.1(cre)Zjh} - Embryo-other
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Cck^{tm1.1(cre)Zjh}
cholecystokinin; targeted mutation 1.1, Z Josh Huang

Driver: Cck
Type: Targeted (Recombinase)

Synonym:

Cck-IRES-Cre

Molecular description:

A targeting vector was designed to insert an internal ribosome entry site (IRES), a cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cholecystokinin locus (Cck). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. The resulting pups harboring the cre targeted mutation were selected. These Cck-IRES-Cre mice were subsequently bred together for several generations (and the FLPe transgene was removed).

Collection:

Neuroscience Blueprint cre

Find mice (IMSR):

Mouse Strains: 2 strains available Cell Lines: 0 lines available

Additional Tissues:

Cck^{tm1.1(cre)Zjh} activity also observed in:

adipose tissue, alimentary system, cardiovascular system, cavities & their linings ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

111 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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