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Cux2tm3.1(cre/ERT2)Mull - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Cux2tm3.1(cre/ERT2)Mull
cut-like homeobox 2; targeted mutation 3.1, Ulrich Mueller 		Driver: Cux2
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Cux2-CreERT2, Cux2-CreERT2
Molecular description: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an FRT-flanked PGK-Neo cassette into the initiation codon of the cut-like homeobox 2 (Cux2) locus. This construct was electroporated into C57BL/6-derived Bruce4 embryonic stem (ES) cells. Chimeric mice were bred to C57BL/6 mice to establish the colony. Next, mutant mice were bred with FLPe-expressing mice on a C57BL/6 congenic background to remove the FRT-flanked PGK-Neo cassette. The resulting Cux2-CreERT2 mice were then bred to C57BL/6J inbred mice for approximately three generations (selecting away from the FLPe transgene).
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Cux2tm3.1(cre/ERT2)Mull activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 43 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory