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Dbx1tm1.1(cre)Mull - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Dbx1tm1.1(cre)Mull
developing brain homeobox 1; targeted mutation 1.1, Ulrich Mueller 		Driver: Dbx1
Type: Targeted (Recombinase)
Synonym: Dbx1-IRES-Cre
Molecular description: A targeting vector was designed to insert an internal ribosomal entry site, nuclear-localized Cre recombinase gene (NLS-Cre), and polyA signal (IRES-Cre-pA), all followed by an FRT-flanked PGK-Neo cassette into the 3' untranslated region of the developing brain homeobox 1 (Dbx1) locus. This construct was electroporated into C57BL/6-derived Bruce4 embryonic stem (ES) cells. Chimeric mice were bred to albino B6(Cg)-Tyrc-2J/J mice. Next, mutant mice were bred with FLPe-expressing mice on a C57BL/6 congenic background to remove the FRT-flanked PGK-Neo cassette. The resulting Dbx1-IRES-Cre mutant mice were then bred to C57BL/6J inbred mice for many generations (selecting away from the FLPe transgene).
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Dbx1tm1.1(cre)Mull activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory