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Tg(Slco1c1-icre/ERT2)1Mash - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slco1c1-icre/ERT2)1Mash
transgene insertion 1, Markus Schwaninger 		Driver: Slco1c1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Slco1c1-CreERT2, Tg(Slco1c1-icre/ERT2)1Mrks
Molecular description: A bacterial artificial chromosome (BAC; RP24-85B20) was modified by homologous recombination to insert a codon-improved cre (icre) fused to a mutated human estrogen receptor ligand-binding domain (ERT2). The targeting construct, which also contained an Frt-flanked ampicillin resistance cassette, was electroporated into bacterial cells containing the BAC. Cells with recombinant BAC clones were induced with L-arabinose to induce Flp recombinase expression to excise the resistance marker. The BAC was isolated, purified and injected into mouse pronuclei to obtain transgenic animals. No founder information was available so line 1 was entered.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slco1c1-icre/ERT2)1Mash activity also observed in:
cardiovascular system, head, nervous system, reproductive system
Images
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J:179050 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory