Runx1<tm2.1(cre/Esr1*)Ims> - Extraembryonic Component Recombinase Activity Detail MGI Mouse

Runx1^{tm2.1(cre/Esr1*)Ims} - Extraembryonic Component
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Runx1^{tm2.1(cre/Esr1*)Ims}
runt related transcription factor 1; targeted mutation 2.1, Igor M Samokhvalov

Driver: Runx1
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Runx1^SACRE

Molecular description:

A targeting vector was composed of the sequence for a tamoxifen-inducible cre recombinase (flanked by two mutated estrogen receptors, MerCreMer) with the Engrailed-2 splice acceptor (En2SA) sequence preceding the coding region and a transcription STOP sequence followed the cre/Esr1*. A floxed neo selection cassette followed the STOP. Insertion of the En2SA sequence prevents splicing of the STOP out and disrupted Runx1 expression from both the proximal P2 and distal P1 promoters. The neo was subsequently deleted from the allele.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Runx1^{tm2.1(cre/Esr1*)Ims} activity also observed in:
cardiovascular system, embryo-other, hemolymphoid system, mesenchyme, reproductive system

Tissue Information

Extraembryonic Component

Other recombinase alleles with activity in Extraembryonic Component tissues:

Alpl^tm1(cre)Nagy, Cdh5^{em1(cre/ERT2)Smoc}, Commd10^{Tg(Vav1-icre)A2Kio}, Edil3^{Tg(Sox2-cre)1Amc} ...(more)

Images

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J:182232 Fig. 4

J:182232 Fig. S8

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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