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Tg(Slc17a8-icre)1Edw - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc17a8-icre)1Edw
transgene insertion 1, Robert H Edwards 		Driver: Slc17a8
Type: Transgenic (Recombinase)
Synonym: VG3-Cre, VGLUT3 Cre BAC
Molecular description: The C57BL/6 mouse bacterial artificial chromosome (BAC) RP24-88H21, containing only the Slc17a8 locus, was modified by targeting a codon optimized cre recombinase (icre), followed by an SV40 polyA signal, into the ATG start site of theSlc17a8 locus. The modified BAC was microinjected into fertilized FVB/N oocytes and transgenic founders were obtained and crossed to mice expressing a cre-dependent reporter. Activity of icre is seen in interneurons in the hippocampus, cortex, striatum, and cerebellum, with some expression seen in amacrine cells of the inner retina. Two of four founder lines expressed cre, and one line was analyzed further.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc17a8-icre)1Edw activity also observed in:
head, nervous system
Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 37 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory