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Tg(Nes-phiC31*)1Imayo - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-phiC31*)1Imayo
transgene insertion 1, Itaru Imayoshi 		Driver: Nes
Type: Transgenic (Recombinase)
Synonym: Nestin-PhiC31o
Molecular description: The construct was composed of a 5.8 kb fragment of the nestin promoter upstream of the sequence for optimized phiC31 recombinase (phiC31*), with the 1.8 kb second intron containing the neural stem/progenitor cell-specific enhancer downstream of the recombinase sequence. The SV40 polyadenylation sequence was also cloned into the vector. The linearized, purified construct was injected into pronuclei of fertilized one-cell embyros. Only one founder line was established. Mice show wide expression of phiC31 mRNA in the nervous system with no expression observed in non-neural tissues like somites. High expression is observed in the ventricular zone of the developing nervous system.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-phiC31*)1Imayo activity also observed in:
head, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory