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Tg(Col11a2-cre)4Nhzi - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Col11a2-cre)4Nhzi
transgene insertion 4, Nobumichi Hozumi 		Driver: Col11a2
Type: Transgenic (Recombinase)
Synonym: alpha2(XI) collagen-Cre line #4
Molecular description: Cre recombinase replaced the beta-galactosidase gene in a construct containing the -742bp Col11a2 promoter sequence, SV40 RNA splice site, lacZ sequence, and Col11a2 first intron. The 4.2 kb construct was microinjected into fertilized pronuclei. 5 founders were obtained. 2 lines (1 and 5) did show recombination in crosses to lacZ reporter mice. Line 2 showed cre activity in neural tissue and line 3 had ubiquitous activity. Line 4 was chosen due to its restricted cre activity pattern, although it had a low transgene copy number compared to the other lines.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Col11a2-cre)4Nhzi activity also observed in:
embryo-other, head, limbs, mesenchyme, mouse-other
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory