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Tg(INS-icre)18Msdr - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(INS-icre)18Msdr
transgene insertion 19, Marlon R Schneider 		Driver: INS
Type: Transgenic (Recombinase)
Synonym: PIP-iCre
Molecular description: A 1055 bp fragment encoding codon-improved cre recombinase was inserted into a vector containing a 1500 bp fragment of the 5' UTR of the porcine insulin promoter (PIP) of the insulin gene (INS). The purified construct was injected into C57BL/6 fertilized oocytes. 43 founders were obtained and two transmitted the transgene to their progeny. These founders were crossed to ROSA26lacZ reporter mice. Founder line 20 did not show any beta-galactosidase activity and was not analyzed further; line 18 displayed staining in essentially all islets, but not in the exocrine compartment and was more fully characterized.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(INS-icre)18Msdr activity also observed in:
alimentary system, head, nervous system, renal & urinary system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:179832 Fig. 2a J:179832 Fig. 2b J:179832 Fig. 2c J:179832 Fig. 2d
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory