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Tg(Myh6-cre/PGR*)6297Mds - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Myh6-cre/PGR*)6297Mds
transgene insertion 6297, Michael D Schneider 		Driver: Myh6
Type: Transgenic (Inducible, Recombinase)
Inducer: mifepristone
Synonym: alphaMHC-Cre
Molecular description: The Myh6 promoter was used to drive cardiac myocyte-specific expression of an inducible cre fused to the mutated ligand-binding domain of human PGR (amino acids 641-891). Three founder lines, 6306, 6297, and 6299, were generated with line 6306 showing the lowest level of cre protein by Western blot and lowest prevalence of ligand-dependent recombination, with 6299 showing the highest level of recombination. Copy number in 6297 was found to be intermediate, greater than 1 but less than in 6299 (c.# 10).
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Myh6-cre/PGR*)6297Mds activity also observed in:
muscle, respiratory system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory