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Cx3cr1tm2.1(cre/ERT2)Litt - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Cx3cr1tm2.1(cre/ERT2)Litt
C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Dan R Littman 		Driver: Cx3cr1
Type: Targeted (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Cx3cr1CreER, CX3CR1YFP-creER
Molecular description: A targeting vector was designed to replace exon 2 of the chemokine (C-X3-C) receptor 1 (Cx3cr1) gene with a cre/ERT2 (cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, followed by an internal ribosome entry site (IRES) and an enhanced yellow fluorescent protein (EYFP). A frt-flanked neomycin resistance cassette, in reverse orientation to the gene, was also inserted downstream of the EYFP sequence. Flp-mediated recombination excised the neomycin resistance sequence.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Cx3cr1tm2.1(cre/ERT2)Litt activity also observed in:
head, hemolymphoid system, nervous system, renal & urinary system, reproductive system, skeletal system
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Images
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J:232845 Full Image
Fig. Cx3cr1 adult Skin
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 262 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory