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Tg(Mchr1-cre)1Emf - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Mchr1-cre)1Emf
transgene insertion 1, Eleftheria Maratos-Flier 		Driver: Mchr1
Type: Transgenic (Recombinase)
Synonym: Mchr1-cre BAC tg
Molecular description: A cre recombinase sequence (1032 bp) was inserted downstream of the Mchr1 promoter on the RP23-202N16 BAC via homologous recombination/BAC recombineering; this replaced nucleotides 4-41 from exon 1 and was designed to disable transcription/translation of the Mchr1 protein from the BAC Mchr1 locus. An frt-flanked kanamycin selection cassette used during homologous recombination/BAC recombineering was removed by transient FLP plasmid injection. The resulting ~198 kbp Mchr1-cre BAC transgene was injected into C57BL/6J embryos to establish transgenic founder animals. Founder animals were bred to C57BL/6J mice to generate independent founder lines. One founder line was chosen.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Mchr1-cre)1Emf activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:266416 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory