Tac1<tm1.1(cre)Hze> - Nervous System Recombinase Activity Detail MGI Mouse

Tac1^{tm1.1(cre)Hze} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Tac1^{tm1.1(cre)Hze}
tachykinin 1; targeted mutation 1.1, Hongkui Zeng

Driver: Tac1
Type: Targeted (Recombinase)

Synonym:

Tac1-IRES2-Cre, Tac1-IRES2-Cre-Delta, Tac1-IRES2-Cre-DeltaNeo/Hygro, Tac1-IRES2-Cre-DeltaNeo/HygroTac1-IRES2-Cre-D

Molecular description:

The targeting vector contained, from 5' to 3', a partial Tac1 sequence spanning intron 4 through intron 6, an frt3 site within Tac1 intron 6, a partial Tac1 exon 7 sequence including the endogenous stop codon, an internal ribosome entry site 2 (IRES2) sequence (allows translation initiation in the middle of a mRNA sequence), a cre recombinase gene, a bovine growth hormone polyA sequence, an AttB site, a PGK promoter-Neomycin resistance gene-PGK polyA cassette, an frt5 site, an mRNA splice acceptor, the 3' portion of the hygromycin gene with SV40 late polyA signal, and an AttP site. This construct was electroporated into (129S6/SvEvTac x C57BL/6)F1-derived G4 ES cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric mice were bred to PhiC31-expressing mice (JAX Stock No. 007743) to remove the AttB/AttP-flanked sequences.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tac1^{tm1.1(cre)Hze} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Images

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J:331457 Fig. 6

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

62 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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