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Fostm1.1(cre/ERT2)Luo - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Fostm1.1(cre/ERT2)Luo
FBJ osteosarcoma oncogene; targeted mutation 1.1, Liqun Luo 		Driver: Fos
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Fos-CreER, FosCreER, FosCreER, Fos-CreERT2, FosCreERT2, FosCreERT2
Molecular description: A targeting vector was designed to insert a cre/ERT2-SV40 polyA cassette followed by an FRT5-flanked pSV40-NeoR-pA cassette into the translational start site of the FBJ osteosarcoma oncogene gene (Fos). The targeting event displaced the introns and coding regions and replaced the endogenous 3' UTRs (which contribute to mRNA destabilization and to Arc mRNA dendritic trafficking) with an exogenous SV40 polyadenylation signal (to promote high-level expression). All sequences 5' to the translational start site are retained. The construct was electroporated into R1 embryonic stem (ES) cells and correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were bred to germline-active GFP-FlpO transgenic mice to delete the FRT5-flanked pSV40-NeoR-pA cassette.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Fostm1.1(cre/ERT2)Luo activity also observed in:
head, nervous system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 52 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory