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Epxtm1.1(cre)Jlee - Hemolymphoid System
Recombinase Activity Detail
Allele Information
Allele:
Epxtm1.1(cre)Jlee
eosinophil peroxidase; targeted mutation 1.1, James J Lee 		Driver: Epx
Type: Targeted (Recombinase)
Synonym: eoCRE
Molecular description: A sequence encoding a mammalian codon-optimized cre recombinase was inserted at the start codon of the Epx locus by homologous recombination. An IRES was inserted before the coding exons of Epx, so that a dicstronic mRNA encoding cre and Epx would be generated. A neo selection cassette was included in the original construct, and was subsequently removed from the targeted allele by a backcross to a flp deleter mouse strain. It was determined that Epx expression was not rescued efficienty from the modified allele by the IRES. Flow cytometric GFP analyses of cell populations from offspring of eoCre mice and reporter animals demonstrated that cre expression is observed only in eosinophils.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Epxtm1.1(cre)Jlee activity also observed in:
alimentary system, integumental system, liver & biliary system, mouse-other
Tissue Information
Hemolymphoid System Other recombinase alleles with activity in Hemolymphoid System tissues:
Images
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J:278280 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory