Myf5<tm1(cre/Esr1*)Trdo> - Renal & Urinary System Recombinase Activity Detail MGI Mouse

Myf5^{tm1(cre/Esr1*)Trdo} - Renal & Urinary System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Myf5^{tm1(cre/Esr1*)Trdo}
myogenic factor 5; targeted mutation 1, Thomas A Rando

Driver: Myf5
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Myf5CreER

Molecular description:

A targeting vector was designed to place an internal ribosome entry site (IRES) fused to a CreERTM fusion gene (CreERTM; Cre recombinase fused to a G525R mutant form of the mouse estrogen receptor ligand binding domain) downstream of the stop codon in exon 3 of the Myf5 gene. A neomycin resistance marker, flanked by frt sites, was inserted downstream of the IRES-CreERTM cassette. This construct was electroporated into R1 embryonic stem cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Myf5^{tm1(cre/Esr1*)Trdo} activity also observed in:
embryo-other, head, limbs, mesenchyme, muscle

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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