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Sox2tm1.1(cre/ERT2)Jpmb - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
Sox2tm1.1(cre/ERT2)Jpmb
SRY (sex determining region Y)-box 2; targeted mutation 1.1, Juan Pedro Martinez Barbera 		Driver: Sox2
Type: Targeted (Inducible, Null/knockout, Recombinase)
Inducer: tamoxifen
Synonym: Sox2CreERT2, Sox2tm1.1(cre)Jpmb
Molecular description: Homologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26YFP and Sox2Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia).
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Sox2tm1.1(cre/ERT2)Jpmb activity also observed in:
alimentary system, endocrine system, head, nervous system
Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory