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Tg(Bmx-cre/ERT2)1Rha - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Bmx-cre/ERT2)1Rha
transgene insertion 1, Ralf H Adams 		Driver: Bmx
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Bmx(PAC)-CreERT2
Molecular description: cDNA encoding cre recombinase fused to the mutated human estrogen receptor ligand-binding domain (ERT2) and followed by a polyadenylation signal and an Frt-flanked neo cassette was inserted into the start codon of the mouse Bmx gene located in the P1 artificial chromosome (PAC; RPCI21) using recombineering methods. Flp-mediated excision in bacteria removed the neo marker. The validated construct was injected into fertilized oocytes to generate founders (details not available). Founders were bred to reporter mice to assess recombination efficiency and specificity; mice display inducible artery-specific cre activity.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Bmx-cre/ERT2)1Rha activity also observed in:
alimentary system, integumental system, limbs, muscle, reproductive system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:198633 Fig. 2 J:198633 Fig. S3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 23 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory