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Tg(Hoxa5-cre)447BLjea - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Hoxa5-cre)447BLjea
transgene insertion 447B, Lucie Jeannotte 		Driver: Hoxa5
Type: Transgenic (Recombinase)
Synonym: Tg(14.5kb Hoxa5-cre)Ljea
Molecular description: A 5 kb genomic fragment of Hoxa5 (containing the temporal (T) control region, the brachial spinal cord (BSC) enhancer, proximal Hoxa5 promoter, both exons and the intron of Hoxa5) drives cre epxression in this transgene. An IRES-EGFPcre cassette was inserted into exon 1 of Hoxa5 downstream of the translation initiation codon. A 2.1 kb fragment containing the mesodermal (MES) enhancer and an additional 7.4-kb of downstream sequences including an enhancer driving lung and gut (L/G) expression were added at the 3' end of the construct to produce the 14.5 Hoxa5/Cre transgene. Eight founder lines were obtained and line 447B was established. This line has 6 copies of the transgene.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Hoxa5-cre)447BLjea activity also observed in:
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:207917 Fig. 1C
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory