Avp<tm1.1(cre)Hze> - Nervous System Recombinase Activity Detail MGI Mouse

Avp^{tm1.1(cre)Hze} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Avp^{tm1.1(cre)Hze}
arginine vasopressin; targeted mutation 1.1, Hongkui Zeng

Driver: Avp
Type: Targeted (Recombinase)

Synonym:

AVP-IRES2-Cre, AVP-IRES2-Cre-D, AVP-IRES2-Cre-DeltaNeo, AVP^{m1(IRES2-Cre)Hze}

Molecular description:

The targeting vector contained, from 5' to 3', a partial Avp sequence spanning exon 1 through intron 1, an frt3 site within Avp intron 1, a partial Avp intron 1 sequence up to and including the endogenous stop codon in exon 3, an internal ribosome entry site 2 (IRES2) sequence (allows translation initiation in the middle of an mRNA sequence), a Cre recombinase gene,a bovine growth hormone polyA sequence, an AttB site, a PGK promoter-Neomycin resistance gene-PGK polyA cassette, an frt5 site, an mRNA splice acceptor, the 3' portion of the hygromycin gene (Hygro2) with SV40 late polyA signal, and an AttP site. This construct was electroporated into (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric mice were bred to PhiC31-expressing mice to remove the AttB/AttP-flanked PGK-neo sequence and replace it with the recombined AttB/AttP site (AttL).

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Avp^{tm1.1(cre)Hze} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

31 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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