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Tg(Tbx21-cre)1Dlc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tbx21-cre)1Dlc
transgene insertion 1, Catherine Dulac 		Driver: Tbx21
Type: Transgenic (Recombinase)
Synonym: Tbet-cre
Molecular description: Cre cDNA was inserted at the start ATG of the Tbx21 gene in a BAC (RP23-237M14). The recombined BAC was linearized and injected into B6/CBA oocytes. 14 animals were generated and one was determined to be positive for the Tbx21-cre transgene. The single founder line was analyzed by immunohistochemistry for cre protein. Strong expression was detected and reporter crosses displayed recombination in the mitral and external tufted layers of the main and accessory olfactory bulbs, with no other brain tissues showing recombination. Activity was also observed in the thymus, a known site of Tbx21 expression.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tbx21-cre)1Dlc activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:315131 Fig. 1 J:315131 Fig. 7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory