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Tg(Gcg-icre)23Cshi - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gcg-icre)23Cshi
transgene insertion 23, Chiyo Shiota 		Driver: Gcg
Type: Transgenic (Recombinase)
Synonym: Gcg-Cre
Molecular description: BAC recombineerting was used to generate a construct with a codon-improved cre recombinase sequence inserted into the translation initiation site in exon 2 of the glucagon (Gcg) gene, followed by n adenylation signal sequence. The large first intron of Gcg was replaced with a 300 bp synthetic intron to reduce the size of the final transgene construct that was injected into pronuclei of C57BL/6 zygotes. Founders were screened by PCR for transgene intregration, with 20 and 23 testing positive for integration. Line 23 was chosen for further analysis.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gcg-icre)23Cshi activity also observed in:
alimentary system, endocrine system, head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory