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Nkx2-2tm4.1(cre/EGFP)Suss - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Nkx2-2tm4.1(cre/EGFP)Suss
NK2 homeobox 2; targeted mutation 4.1, Lori Sussel 		Driver: Nkx2-2
Type: Targeted (Null/knockout, Recombinase)
Synonym: Nkx2.2Cre, Nkx2.2:Cre-EGFP
Molecular description: A cre/EGFP fusion gene and Frt-flanked hygro selection cassette were inserted using recombineering into an Nkx2-2 basal exchange vector such that cre/EGFP was fused in-frame with the ATG start codon, replacing all but 25 base pairs of the first coding exon. This vector was co-injected with a cre-expression vector into ES cells containing an Nkx2-2 (loxed cassette acceptor) allele. Correctly exchanged ES clones were used to produce chimeras which were bred to B6 mice to verify germline transmission. Animals were bred to ACTB-Flpe mice to excise the hygromycin marker.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Nkx2-2tm4.1(cre/EGFP)Suss activity also observed in:
alimentary system, endocrine system, head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:204532 Fig. 3 J:204532 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory