About   Help   FAQ
Sox17tm4.1(icre/ERT2)Heli - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Sox17tm4.1(icre/ERT2)Heli
SRY (sex determining region Y)-box 17; targeted mutation 4.1, Heiko Lickert
Driver: Sox17
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Sox17CreERT2, Sox17CreERT2deltaneo
Molecular description: A targeting vector was designed to delete the translational stop codon of Sox17 and to introduce the codon-optimized cre fused to the triple-mutant (G400V, M543A and L544A) human estrogen receptor ligand binding domain (ERT2) sequence preceded by a viral 2A peptide sequence into exon 5. Homologous recombination in ES cells integrated the cre/ERT2 cassette and Frt-flanked neomycin marker so that the targeted Sox17 allele will produce an bicistronic mRNA that will be co-translationally cleaved into equimolar amounts of Sox17 and cre. Chimeras were crossed to a Flp deleter line to remove the neo selection marker.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Sox17tm4.1(icre/ERT2)Heli activity also observed in:
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:204611 Fig. 2 J:204611 Fig. 3 J:204611 Fig. 4 J:204611 Fig. S1
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory