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Sox17tm4.1(icre/ERT2)Heli - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Sox17tm4.1(icre/ERT2)Heli
SRY (sex determining region Y)-box 17; targeted mutation 4.1, Heiko Lickert 		Driver: Sox17
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Sox17CreERT2, Sox17CreERT2deltaneo
Molecular description: A targeting vector was designed to delete the translational stop codon of Sox17 and to introduce the codon-optimized cre fused to the triple-mutant (G400V, M543A and L544A) human estrogen receptor ligand binding domain (ERT2) sequence preceded by a viral 2A peptide sequence into exon 5. Homologous recombination in ES cells integrated the cre/ERT2 cassette and Frt-flanked neomycin marker so that the targeted Sox17 allele will produce an bicistronic mRNA that will be co-translationally cleaved into equimolar amounts of Sox17 and cre. Chimeras were crossed to a Flp deleter line to remove the neo selection marker.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Sox17tm4.1(icre/ERT2)Heli activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:204611 Fig. 2 J:204611 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory