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Allele Information
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Allele:
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Sox17tm4.1(icre/ERT2)Heli
SRY (sex determining region Y)-box 17;
targeted mutation 4.1, Heiko Lickert
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Driver: Sox17
Type: Targeted
(Inducible, Recombinase)
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Inducer:
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tamoxifen
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Synonym:
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Sox17CreERT2, Sox17CreERT2deltaneo
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Molecular description:
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A targeting vector was designed to delete the translational stop codon of Sox17 and to introduce the codon-optimized cre fused to the triple-mutant (G400V, M543A and L544A) human estrogen receptor ligand binding domain (ERT2) sequence preceded by a viral 2A peptide sequence into exon 5. Homologous recombination in ES cells integrated the cre/ERT2 cassette and Frt-flanked neomycin marker so that the targeted Sox17 allele will produce an bicistronic mRNA that will be co-translationally cleaved into equimolar amounts of Sox17 and cre. Chimeras were crossed to a Flp deleter line to remove the neo selection marker.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Sox17tm4.1(icre/ERT2)Heli activity also observed in:
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Tissue Information
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Extraembryonic Component
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Other recombinase alleles with activity in Extraembryonic Component tissues:
Alpltm1(cre)Nagy,
Cdh5em1(cre/ERT2)Smoc,
Commd10Tg(Vav1-icre)A2Kio,
Edil3Tg(Sox2-cre)1Amc,
Elf5em1(cre)Jilu,
Eomestm4.1(icre)Rob,
Esrrbtm1(cre)Yba,
Fgf18tm2.2(cre/ERT2)Dor,
Foxa2tm2.1(cre/Esr1*)Moon,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Hlfem2(cre/ERT2)Suda,
Hnf4atm1(cre)Sdv,
Hoxa13tm1.1(cre)Mlkn,
Hoxa13tm1(cre)Mlkn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Kdrtm1(cre)Sato,
Kittm1(cre/ERT2)Dsa,
Krt19tm1(cre)Mmt,
Mapttm1(cre)Nagy,
Mecomem1(cre/ERT2)Suda,
Meox2tm1(cre)Sor,
Mesp1tm2(cre)Ysa,
Nfatc1em4(cre/ERT2)Bzsh,
Nkx1-2tm2296.1(cre/ERT2)Arte,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Prdm1tm3(icre)Rob,
Prl2c2tm1(cre)Gle,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm2(cre/ERT2)Cjt,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Synbem1(cre)Mdf,
Taglntm2(cre)Yec,
Tg(ACTA1-cre)79Jme,
Tg(Acvrl1-cre)L1Spo,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Cdx1-cre)23Kem,
Tg(Csf1r-cre/Esr1*)1Jwp,
Tg(Cyp19a1-cre)5912Gle,
Tg(Ddx4-cre)1Dcas,
Tg(EIIa-cre)C5379Lmgd,
Tg(Etv2-cre)15508Djg,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tg(Foxa3-cre)1Khk,
Tg(Gata1-cre)1Sho,
Tg(Gcm1-cre)1Chrn,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre)#Mku,
Tg(Hspa2-cre)1Eddy,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Lefty1-cre/ERT2)8Hmd,
Tg(Nes-cre)1Atp,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Prrx1-cre)1Cjt,
Tg(Sim1-cre)1Lowl,
Tg(Smarcd3-cre/ERT2)#Bbr,
Tg(Sox2-flpo)#Mhem,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Ymor,
Tg(Tpbpa-cre,-EGFP)5Jcc,
Tg(Ttr-cre)1Hadj,
Tg(Vav1-cre)8Cgp,
Tg(Vil1-cre)20Syr,
Tg(Wnt11-cre/ERT2)1Jwng,
Twist2tm1.1(cre)Dor
(less)
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Images
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J:204611
Fig. 2
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Recombinase Activity
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References
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Analysis Tools