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Esr1tm1.1(cre)And - Head
Recombinase Activity Detail
Allele Information
Allele:
Esr1tm1.1(cre)And
estrogen receptor 1 (alpha); targeted mutation 1.1, David J Anderson 		Driver: Esr1
Type: Targeted (RMCE-ready, Recombinase)
Synonym: Esr1cre, Esr1cre
Molecular description: The Esr1-cre targeting vector was designed to insert an attP site, a 2A oligopeptide (mediates ribosomal skipping), the Cre recombinase gene, a frt-flanked PGKneo-polyA cassette, and an attP site within the 3' UTR of the estrogen receptor 1 alpha gene (Esr1). The targeting construct was electroporated into 129S6/SvEvTac-derived TC-1 embryonic stem (ES) cells. Chimeric males were bred with 129S6/SvEvTac females to establish the colony. Heterozygotes were bred to ACT-FLPe mice to remove the frt-flanked PGKneo-polyA cassette. Mice were bred to remove the ACT-FLPe transgene from the background.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Esr1tm1.1(cre)And activity also observed in:
nervous system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:207677 Fig. 1 J:207677 Fig. S1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 35 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory