Crh<tm1.1(cre)Dolsn> - Head Recombinase Activity Detail MGI Mouse

Crh^{tm1.1(cre)Dolsn} - Head
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Crh^{tm1.1(cre)Dolsn}
corticotropin releasing hormone; targeted mutation 1.1, David P Olson

Driver: Crh
Type: Targeted (Recombinase)

Synonym:

Crf^cre, CRF-ires-Cre, Crh-IRES-Cre

Molecular description:

A selection cassette containing an internal ribosomal entry sequence (IRES) linked to cre and an frt-flanked kanamycin gene was inserted immediately downstream of the stop codon in exon 1 of the Crh gene contained in a BAC using recombineering methods. This construct was used to isolate a targeting plasmid with the cre-kanamycin cassette with upstream and downstream Crh homology arms. ES cells were targeted and used for blastocyst injection. Chimeras were bred for germline transmission. The selection marker was excised by breeding to Flp deleter animals.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Crh^{tm1.1(cre)Dolsn} activity also observed in:
nervous system

Tissue Information

Head

Other recombinase alleles with activity in Head tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acan^{tm1(cre/ERT2)Crm}, Acsm4^tm1(cre)Hsak ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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