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Tg(Hcn4-cre/ERT2)1Yzhao - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Hcn4-cre/ERT2)1Yzhao
transgene insertion 1, Yong Zhao 		Driver: Hcn4
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Hcn4-CreERT2
Molecular description: Recombineering methods were used to insert a cre/ERT2 cassette immediately after the ATG start codon of the Hcn4 locus in a bacterial artificial chromosome (this BAC does not encode other proteins or micro RNAs). The BAC construct was purified and used for pronuclear injection of fertilized oocytes. Two founders were generated, with essentially identical cre activity patterns following tamoxifen treatment being observed. One line was chosen for detailed analyses.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Hcn4-cre/ERT2)1Yzhao activity also observed in:
respiratory system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:207828 Fig. 2 J:207828 Fig. S1 J:207828 Fig. S2 J:207828 Fig. S4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory