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Allele Information
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Allele:
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Inducer:
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tamoxifen
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Synonym:
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Hcn4-CreERT2
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Molecular description:
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Recombineering methods were used to insert a cre/ERT2 cassette immediately after the ATG start codon of the Hcn4 locus in a bacterial artificial chromosome (this BAC does not encode other proteins or micro RNAs). The BAC construct was purified and used for pronuclear injection of fertilized oocytes. Two founders were generated, with essentially identical cre activity patterns following tamoxifen treatment being observed. One line was chosen for detailed analyses.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Hcn4-cre/ERT2)1Yzhao activity also observed in:
cardiovascular system
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Tissue Information
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Respiratory System
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Other recombinase alleles with activity in Respiratory System tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Acantm1(cre/ERT2)Crm,
Agertm2.1(cre/ERT2)Blh,
Agrptm1(cre)Lowl,
Aldh1l1em1(cre/ERT2)Nju,
Alpltm1(cre)Nagy,
Amhr2em1(icre)Fjd,
Aplnrem3(cre/ERT2)Smoc,
Atoh8tm1(EGFP/cre)Gasa,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Ccr2em1(mNeonGreen,cre)Cya,
Cd34tm1.1(cre/ERT2)Lizg,
Cdh5em1(nigri)Bzsh,
Cdkn2atm1.1(cre)Dvb,
Cdkn2atm1(cre/ERT2)Mkt,
Cfap126tm1.1(icre)Heli,
Chia1tm1.1(icre)Lky,
Cldn6tm1(cre/ERT2)Dam,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Corttm1(cre)Zjh,
Crhtm1(cre)Zjh,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
Ddx4em1(icre)Jobo,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Elf5em1(cre)Jilu,
Eportm1.1(EGFP/icre)Uk,
Etv5tm1(cre/ERT2)Brst,
Fgf10tm2.1(cre/ERT2)Sbel,
Fgf16tm1.1(cre)Sms,
Fgf18tm2.2(cre/ERT2)Dor,
Foxa2tm1(cre)Heli,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxd1tm1(GFP/cre)Amc,
Foxj1tm1.1(cre/ERT2/GFP)Htg,
Fstl1tm2.1(cre/ERT2)Ning,
Gad2tm2(cre)Zjh,
Gata4tm2(cre/ERT2)Ykaw,
Gfi1tm1(cre)Gan,
Gli2tm1(cre/ERT2)Tipe,
Glp1rtm1.1(cre)Cors,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hlfem2(cre/ERT2)Suda,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Hsd11b2tm1(cre)Anft,
Ifi208Tg(Cspg4-cre)1Akik,
Igs2tm1(Cdkn1a-cre/ERT2,-EGFP)Mxu,
Il1r1tm1(cre/ERT2)Jhle,
Itga8tm1.1(cre/ERT2)Jomm,
Kittm1.1(cre)Jmol,
Kittm1(cre/ERT2)Bzsh,
Kittm2.1(cre/Esr1*)Jmol,
Krt17tm1(cre)Murr,
Leprtm2(cre)Rck,
Lgr4tm1(cre/ERT2)Cle,
Lgr5tm1.1(cre/ERT2)Npa,
Lgr6tm2.1(cre/ERT2)Cle,
Ltftm1(icre)Tdku,
Ly6atm1.1(cre/ERT2)Geno,
Ly6atm2.1(cre/Esr1*)Jmol,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mcoln3tm1.1(cre)Lrcb,
Mecomtm4.1(cre/ERT2)Aspe,
Mfsd2atm2(cre/ERT2)Dls,
Mnx1tm4(cre)Tmj,
Msi2tm1.1(cre/ERT2)Reya,
Myf5tm3(cre)Sor,
Myh6em2(cre)Smoc,
Myocdtm1(cre)Dzw,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx2-1tm1.1(cre/ERT2)Zjh,
Nkx2-5tm2(cre)Rph,
Oprk1tm1.1(cre)Sros,
Osr2tm2(cre)Jian,
P2rx2tm1.1(cre)Ttc,
P2ry12em1(icre/ERT2)Tda,
Pax3tm1(cre)Joe,
Pax7tm2.1(cre/ERT2)Fan,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(cre/ERT2)Blh,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Piezo1em2(cre/ERT2)Smoc,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Prlrtm1.1(cre)Uboe,
Rbpmsem1(cre/ERT2)Yzhe,
Rtkn2em1(cre/ERT2)Jich,
Scgb1a1tm1.1(Cicre)Thbr,
Scgb1a1tm1(cre/ERT)Blh,
Sfta3tm1.1(cre/ERT2)Eem,
Sftpctm1.1(Nicre)Thbr,
Sftpctm1(dre/ERT2)Bzsh,
Shhtm1(EGFP/cre)Cjt,
Slc17a6tm2(cre)Lowl,
Slc26a9em1(cre)Sms,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sox2tm1.1(cre/ERT2)Ykaw,
Spink1tm3(cre)Kymm,
Taglntm2(cre)Yec,
Tas2r131tm2.1(cre)Uboe,
Tbx21tm1.1(cre/ERT2)Ayr,
Tekem1(dre)Bzsh,
Tfcp2l1tm1.1(cre/ERT2)Ovi,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTB-cre)1Tes,
Tg(Acvrl1-cre)B1Spo,
Tg(Acvrl1-cre)L1Spo,
Tg(Aldh1l1-cre/ERT2)02Kan,
Tg(Amh-cre)8815Reb,
Tg(Amy2-cre)1Herr,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)1Nobs,
Tg(Ccr2-cre)584Hohl,
Tg(CD2-icre)4Kio,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cga-cre)3Sac,
Tg(Chst4-cre)1Hkwa,
Tg(Ckmm-cre)5Khn,
Tg(CMA1-cre)6Thhe,
Tg(CMV-cre)1Cgn,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre/ERT)KA3Smac,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Csrp1-cre)1Sjc,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp17a1-icre)AJako,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(Dll1-cre)33Dchp,
Tg(Dlx1-cre)RB27Gsat,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Elf5-cre/ERT2,-GFP)2Rcha,
Tg(Eno2-cre)39Jme,
Tg(Epo-cre)44Mym,
Tg(Epx-EYFP/cre)#Voeh,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tg(Fgfr3-icre/ERT2)4-2Wdr,
Tg(FOXJ1-cre/ERT2)1Blh,
Tg(FOXJ1-cre)F26Htzm,
Tg(Fzd9-cre)1Chzh,
Tg(Gabra6-cre)B1Lfr,
Tg(Gata1-cre)1Sho,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)77.6Mvs,
Tg(GH1-cre)1Sac,
Tg(Gjb6-cre/ERT2)53-33Fwp,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxa5-cre)447BLjea,
Tg(Hspa2-cre)1Eddy,
Tg(Itgax-cre)1-1Reiz,
Tg(Kdr-cre)15962Brei,
Tg(KRT14-cre/Esr1*)3Brst,
Tg(KRT5-cre)5132Jlj,
Tg(KRT5-cre/ERT2)1Blh,
Tg(KRT5-cre/ERT)SCmch,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(Lck-icre)3779Nik,
Tg(Lyve1-cre/ERT2)49Rtem,
Tg(Mafg-Nrf2/cre,-EGFP)737Hozu,
Tg(Mef2c-cre)2Blk,
Tg(mI56i-cre)6-2Clou,
Tg(MMTV-cre)4Mam,
Tg(MMTV-flpo)11Gcr,
Tg(Mrgprb2-EGFP/cre)#Xzd,
Tg(Mx1-cre)1Cgn,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-icre/ERT2)1Soff,
Tg(Myh6-cre)2182Mds,
Tg(Myh6-cre/PGR*)6297Mds,
Tg(myl7.L-cre)1118Tmhn,
Tg(MYOD1-cre)M23Glh,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nkx2-1-cre)2Sand,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Pcp2-cre)2Mpin,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/ERT2)#Jfm,
Tg(Plp1-cre/ERT)3Pop,
Tg(Prdm1-cre)1Masu,
Tg(Prrx1-cre)1Cjt,
Tg(Retnla-cre)#Voeh,
Tg(Runx1/Hspa1a-cre/ERT2)#Itoy,
Tg(S100a4-cre)1Egn,
Tg(Scgb1a1-cre)1Grau,
Tg(Scgb1a1-cre)1Tauc,
Tg(Scnn1a-cre)3Aibs,
Tg(Scx-cre)HShuk,
Tg(Sftpa1-cre)1Xya,
Tg(SFTPC-cre)11Yo,
Tg(Sftpc-cre)1Blh,
Tg(Sim1-cre)1Lowl,
Tg(Slc1a3-cre/ERT2)45-72Fwp,
Tg(Smad7-cre)1Sjc,
Tg(Stra8-icre)1Reb,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(Tas2r143-cre/ERT2)#Soff,
Tg(Tbx4-cre)6Kras,
Tg(Tbx4-cre/ERT2)#Kras,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-icre/ERT2)1Soff,
Tg(tetO-cre)1Jaw,
Tg(tetO-cre)LC1Bjd,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(TNS4-cre)1Shlo,
Tg(Tshb-cre)4Sac,
Tg(Vil1-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt11-cre/ERT2)1Jwng,
Tg(WT1-cre)AG11Dbdr,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Tigitem1(cre/ERT2)Tebi,
Tmprss2tm1.1(cre/ERT2)Ychen,
Tnfrsf19tm1.1(cre/ERT2)Cle,
Trpm5tm1.1(cre)Uboe,
Trpv4em1(cre/ERT2)Amc,
Twist2tm1.1(cre)Dor,
Vimem1(cre/ERT2)Bzsh,
Viptm1(cre)Zjh,
Wt1tm1(EGFP/cre)Wtp,
Wt1tm2(cre/ERT2)Wtp
(less)
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Images
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J:207828
Fig. 2
J:207828
Fig. S3
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Recombinase Activity
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References
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Analysis Tools