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Pdyntm1.1(cre)Mjkr - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Pdyntm1.1(cre)Mjkr
prodynorphin; targeted mutation 1.1, Michael J Krashes 		Driver: Pdyn
Type: Targeted (Recombinase)
Synonym: Dyn-Cre, Pdyn-IRES-Cre, Prodynorphin-cre
Molecular description: Using recombineering methods, a selection cassette containing an internal ribosomal entry sequence (IRES) linked to cre and an frt-flanked kanamycin gene was inserted immediately downstream of the stop codon in exon 2 of the Pdyn gene in a BAC. This construct was used to isolate a targeting plasmid with the cre-kanamycin cassette with upstream and downstream Pdyn homology arms. ES cells were targeted and used for blastocyst injection. Chimeras were bred for germline transmission. The selection marker was excised by breeding to Flp deleter animals.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Pdyntm1.1(cre)Mjkr activity also observed in:
head, nervous system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 59 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory