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Tg(Gata1-icre)1Jtp - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gata1-icre)1Jtp
transgene insertion 1, Josef T Prchal 		Driver: Gata1
Type: Transgenic (Recombinase)
Synonym: Gata-1-HRD-iCre
Molecular description: A construct was generated by inserting the icre (improved cre) cDNA between the promoter region and polyA site in the IE3.9intpolyAA construct (containg the Gata1-HRD promoter (HRD; hematopoietic regulatory domain)). The transgenic vector was verified by sequencing, linearized and used for pronuclear injection. Three transgenic founders were identified from 16 chimeras, and cre activity was assessed in progeny of crossed to ROSA26 reporter animals. Reporter activation was detected only in bone marrow cells (in early erythroid progenitors) and not in any other organ or tissue examined. The line with greatest cre activity was selected for further analyses.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gata1-icre)1Jtp activity also observed in:
hemolymphoid system, limbs
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory