Tg(Upk2-icre/ERT2)1Ccc - Head Recombinase Activity Detail MGI Mouse

Tg(Upk2-icre/ERT2)1Ccc - Head
Recombinase Activity Detail

Allele Information | Images | Recombinase Activity | References

Allele Information

Allele:

Tg(Upk2-icre/ERT2)1Ccc
transgene insertion 1, Carlos Cordon-Cardo

Driver: Upk2
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

TgUICBAC

Molecular description:

The bMQ-343M5 mouse bacterial artificial chromosome (BAC) containing the entire Upk2 gene (and parts of the Foxr1 and Cxcr5 genes, and the Bcl9l gene) was modified by inserting the icre/ERT2 fusion protein-coding sequence followed by a polyA signal into the ATG initiation start site of the Upk2 gene. The transgenic construct was injected into fertilized C57BL/6 x CBA)F1 mouse eggs. Two founders were obtained (#1 having 2 copies of the transgene and #5 with 4 copies). Only #1 was able to produce offspring, and this line was used for further analyses.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Upk2-icre/ERT2)1Ccc activity also observed in:
renal & urinary system

Images

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J:209640 Fig. 4

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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