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Tg(Upk2-icre/ERT2)1Ccc - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Upk2-icre/ERT2)1Ccc
transgene insertion 1, Carlos Cordon-Cardo 		Driver: Upk2
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: TgUICBAC
Molecular description: The bMQ-343M5 mouse bacterial artificial chromosome (BAC) containing the entire Upk2 gene (and parts of the Foxr1 and Cxcr5 genes, and the Bcl9l gene) was modified by inserting the icre/ERT2 fusion protein-coding sequence followed by a polyA signal into the ATG initiation start site of the Upk2 gene. The transgenic construct was injected into fertilized C57BL/6 x CBA)F1 mouse eggs. Two founders were obtained (#1 having 2 copies of the transgene and #5 with 4 copies). Only #1 was able to produce offspring, and this line was used for further analyses.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Upk2-icre/ERT2)1Ccc activity also observed in:
renal & urinary system
Images
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J:209640 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory