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Hprt1tm364a(CAG-icre/ERT2)Ems - Cavities & Their Linings
Recombinase Activity Detail
Allele Information
Allele:
Hprt1tm364a(CAG-icre/ERT2)Ems
hypoxanthine phosphoribosyltransferase 1; targeted mutation 364a, Elizabeth M Simpson 		Driver: CAG
Type: Targeted (Conditional ready, Inducible, Recombinase)
Inducer: tamoxifen
Synonym: CAGGS-creERT2, CAGGS-icre/frt/ERT2/frt, Hprttm364a(CAGGS-icre/ERT2)Ems, mEMS6096
Molecular description: The transgene was designed with an HS4 insulator region, the 1723 bp ubiquitous CAGGS promoter (CMV early enhancer/chicken beta actin), a chimeric intron cassette, the iCre/ERT2 fusion gene (with F3-frt sites flanking the ERT2 sequences), the mut6-WPRE element, an SV40 early polyA signal, an additional HS4 insulator region, a human HPRT complementary sequence (containing exon 1, intron 1, exon 2, and part of intron 2), a mouse 3' Hprt homology arm, an I-Sce linearization cut site, and a mouse 5' Hprt homology arm.
Collection: EUCOMMTOOLS
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Hprt1tm364a(CAG-icre/ERT2)Ems activity also observed in:
Tissue Information
Cavities & Their Linings Other recombinase alleles with activity in Cavities & Their Linings tissues:
Images
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J:260776 Full Image
Fig. Hprt E15.5 diaphragm J:260776 Full Image
Fig. Hprt E15.5 pericardialcavity J:260776 Full Image
Fig. Hprt E15.5 pericardium
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory