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Allele Information
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Allele:
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Lgr5tm1.1(cre/ERT2)Npa
leucine rich repeat containing G protein coupled receptor 5;
targeted mutation 1.1, Novartis Pharma AG
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Driver: Lgr5
Type: Targeted
(Inducible, Null/knockout, Recombinase, Reporter)
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Inducer:
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tamoxifen
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Synonym:
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Lgr5-EGFP-IRES-CreERT2, Lgr5ki
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Molecular description:
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The targeting construct replaced the first 22 amino acids with an EGFP reporter gene, IRES, inducible cre recombinase fusion (cre/ERT2), polyadenylation sequence and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. In situ hybridization confirmed the absence of transcript expression in the intestin, skin and kidney.
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Find mice (IMSR):
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Mouse Strains:
0 strains available
Cell Lines:
0 lines available
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Additional Tissues:
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Lgr5tm1.1(cre/ERT2)Npa activity also observed in:
alimentary system,
renal & urinary system,
respiratory system
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Tissue Information
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Integumental System
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Other recombinase alleles with activity in Integumental System tissues:
Agrptm1(cre)Lowl,
Airetm3(cre)Mmat,
Alpltm1(cre)Nagy,
Atoh8tm1(EGFP/cre)Gasa,
Axin2tm1(cre/ERT2)Rnu,
Bcl11atm1.1(cre/ERT2)Khal,
Cacna1htm2.1(cre)Glwn,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdkn2atm1(cre/ERT2)Mkt,
Chattm2(cre)Lowl,
Cldn6tm1(cre/ERT2)Dam,
Clec9atm2.1(icre)Crs,
Clutm2(EGFP/cre/ERT2)Wtsi,
Commd10Tg(Vav1-icre)A2Kio,
Corintm2(cre)Bamo,
Crhtm1(cre)Zjh,
Cx3cr1tm2.1(cre/ERT2)Litt,
Dctem1(cre/ERT2)Enis,
Dcttm1(cre)Bee,
Dkk1tm1(cre/ERT2)Pmy,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
En1tm2(cre)Wrst,
Epxtm1.1(cre)Jlee,
Foxd1tm1(GFP/cre)Amc,
Gad2tm2(cre)Zjh,
Gfi1tm1(cre)Gan,
Ghem1(cre)Jmz,
Giprem1(icre)Reim,
Gli1tm3(cre/ERT2)Alj,
Glp1rtm1.1(cre)Cors,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Brn,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm6(dre/PGR*)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hoxc8tm2.1(cre)Mrc,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Hsd11b2tm1(cre)Anft,
Ifi208Tg(Cspg4-cre)1Akik,
Ihhem1(Tomm20/mKate2,dre)Xya,
Kittm1.1(cre)Jmol,
Kittm1(cre/ERT2)Bzsh,
Kittm2.1(cre/Esr1*)Jmol,
Krt14tm1.1(cre/ERT2)Hjg,
Krt14tm1.1(cre)Wbm,
Krt14tm1(cre)Wbm,
Krt17tm1(cre)Murr,
Krt6aem1(icre)Vk,
Leprem2(cre/ERT2)Smoc,
Leprtm2(cre)Rck,
Lgr5em1(cre/ERT2)Kba,
Lgr5tm1(cre/ERT2)Cle,
Lgr6tm2.1(cre/ERT2)Cle,
Lrig1tm1.1(cre/ERT2)Rjc,
Lrig1tm1(cre/ERT2)Kjen,
Lrig1tm2.1(icre/ERT2)Mrc,
Ltftm1(icre)Tdku,
Lyve1tm1.1(EGFP/cre)Cys,
Mcm2tm1(cre/ERT2)Scpr,
Megf6em3(cre)Zzhg,
Mnx1tm4(cre)Tmj,
Mrgprdtm1.1(cre/ERT2)Wql,
Myf5tm3(cre)Sor,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Oca2tm1(cre/ERT2)Mymi,
Omptm4(cre)Mom,
Opn3em1(cre)Lan,
Opn5em1(cre)Lan,
Osr2tm2(cre)Jian,
Oxtrtm3.1(Oxtr*,cre)Knis,
Pax3tm1.1(cre/ERT2)Lepr,
Pax3tm1(cre)Joe,
Pbx3tm1(EGFP/cre/ERT2)Wtsi,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pdgfratm2.2(flpo)Leol,
Pdgfrbtm1.2(flpo)Leol,
Piezo2tm1.1(cre)Apat,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Pmelem1(rtTA,tetO-icre)Osaw,
Prdm1tm3(icre)Rob,
Prdm1tm5.1(cre/ERT2)Rob,
Prlrtm1.1(cre)Uboe,
Procrtm1.1(cre/ERT2)Yaz,
Pvalbtm1(cre)Arbr,
Scn9aem1(icre)Itsu,
Shhtm1(EGFP/cre)Cjt,
Shhtm2(cre/ERT2)Cjt,
Slc17a6tm2(cre)Lowl,
Smoc2tm1(cre/ERT2)Cle,
Sox9em1(cre/ERT2)Tchn,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tbx3em1(cre/ERT2)Toyo,
Tcf7l1tm1.1(cre/ERT2)Hng,
Tg(ACTA1-cre)1Mll,
Tg(ACTA1-cre)79Jme,
Tg(Actl6b-cre)4092Jiwu,
Tg(Adipoq-cre)1Evdr,
Tg(Aire-cre)410-5Mmat,
Tg(Bmx-cre/ERT2)1Rha,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)1Nobs,
Tg(CD2-icre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Cdx2-cre)R337Npln,
Tg(Ckmm-cre)5Khn,
Tg(CMV-cre)1Cgn,
Tg(CMV-cre/ERT)1Ipc,
Tg(Col10a1-cre)1Xya,
Tg(Col1a1-cre)1Kry,
Tg(Col1a1-cre/ERT2)1Crm,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT,-ALPP)7Cpd,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Cryaa-cre)10Mlr,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Cyp39a1-cre)1Aibs,
Tg(Ddx4-cre)1Dcas,
Tg(dlx5a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Elf5-cre/ERT2,-GFP)2Rcha,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Abel,
Tg(Fabp4-cre)1Rev,
Tg(Fabp4-cre/ERT2)1Ipc,
Tgfb3tm1(cre)Vk,
Tg(Flt1-cre/ERT2)1Tmak,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(GH1-cre)1Sac,
Tg(Ghrhr-cre)3242Lsk,
Tg(Grem1-cre/ERT)3Tcw,
Tg(Grik4-cre)G32-4Stl,
Tg(Hoxa5-cre)444CLjea,
Tg(Hoxa5-cre)447BLjea,
Tg(Hoxb8-cre)1403Uze,
Tg(hs1163-Ccre,-lacZ)1Fawa,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(Il7-cre)CRche,
Tg(Ins2-cre)25Mgn,
Tg(Islr-cre/ERT2)#Tobe,
Tg(Itgax-cre)1-1Reiz,
Tg(Klf4-cre/ERT)1Wai,
Tg(Krt10-cre/ERT)#Efu,
Tg(Krt1-15-cre/PGR*)22Cot,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)1Efu,
Tg(KRT14-cre)1Ipc,
Tg(KRT14-cre)43Smr,
Tg(KRT14-cre)8Brn,
Tg(KRT14-cre/ERT)20Efu,
Tg(KRT14-cre/ERT2)1Ipc,
Tg(KRT14-cre/PGR)1Der,
Tg(Krt1-5-cre/ERT)1Ipc,
Tg(Krt15-cre/ERT2)1Johu,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Krt2-6a-cre)1Ism,
Tg(KRT5-cre)5132Jlj,
Tg(KRT5-cre/ERT2)2Ipc,
Tg(KRT5-cre/ERT2)#Mym,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(KRT5-cre/PGR)1Der,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(LGB-cre)74Acl,
Tg(LTF-EGFP/cre/PGR)15Klin,
Tg(Lyve1-cre/ERT2)49Rtem,
Tgm3tm2(EGFP/cre/ERT2)Wtsi,
Tg(Mitf-cre)710-59Gsb,
Tg(Mitf-cre)7114Gsb,
Tg(MMTV-cre)105Ayn,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(MMTV-cre)7Mul,
Tg(MMTV-cre)AElee,
Tg(MMTV-cre)BElee,
Tg(MMTV-cre)#Mam,
Tg(MMTV-flpo)11Gcr,
Tg(MMTV-flpo)29542Kuw,
Tg(MMTV-flpo)9Gcr,
Tg(Mpz-cre)94Imeg,
Tg(Mrgprb2-EGFP/cre)2Xzd,
Tg(Mrgprb2-EGFP/cre)3Xzd,
Tg(Mrgprb2-EGFP/cre)#Xzd,
Tg(Msx2-cre/ERT2)1Nono,
Tg(Msx2-cre/ERT2)2Nono,
Tg(Mx1-cre)1Cgn,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Ntrk3-cre/ERT2)#Phep,
Tg(Pax3-cre)1Joe,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pdpn-cre)HRkl,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Pitx2-cre/Esr1*)#Hmd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Plp1-cre/ERT)3Pop,
Tg(Pou3f4-cre)32Cren,
Tg(Prdm1-cre)1Masu,
Tg(Prrx1-cre)1Cjt,
Tg(Prrx1-mTFP1,-cre/ERT2)1Etnka,
Tg(Relb-cre)53Rie,
Tg(Retn-cre)1Laz,
Tg(Retnla-cre)#Voeh,
Tg(Rr437-cre)#Hmd,
Tg(rtetR-tetO-cre)40Mhz,
Tg(S100a4-cre)1Egn,
Tg(S100a4-cre)1Gle,
Tg(S100a4-flpo)3Lba,
Tg(S100b-cre)20Ito,
Tg(Scnn1a-cre)3Aibs,
Tg(Sim1-cre)1Lowl,
Tg(Stab2-icre)1.2Cger,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)3Fech,
Tg(TCF/Lef1-cre/ERT2)#Ypc,
Tg(Tek-cre)1Ywa,
Tg(Tek-icre/ERT2)1Soff,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre)1Lru,
Tg(Tyr-cre)2Lru,
Tg(Tyr-cre)3Gfk,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Tyr-cre/ERT2)1Lru,
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde,
Tg(Tyr-cre)#Lru,
Tg(Ucp1-cre)1Evdr,
Tg(Ucp1-cre)#Brsp,
Tg(Wap-cre)11738Mam,
Tg(Wap-cre)1Gsc,
Tg(Wap-rtTA-cre)10Whl,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt7a-EGFP/cre)#Bhr,
Tg(WT1-cre)1Asc,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Tmprss2tm1.1(cre/ERT2)Ychen,
Trpv4em1(cre/ERT2)Amc,
Twist2tm1.1(cre)Dor,
Ucp1em1(cre)Chez,
Vimem1(cre/ERT2)Bzsh,
Wt1tm1(EGFP/cre)Wtp
(less)
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Images
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J:212415
Fig. 4
J:212415
Fig. S6
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Recombinase Activity
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References
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Analysis Tools